Getting Knowledge Translation in Integrative Oncology

MODERATOR: Eva Grunfeld, MSc, MD, DPhil, FCFP
  Sunita Vohra, MD
Dugald Seely, ND, MSc, FABNO
Lynda Balneaves, PhD, RN
Michelle Kohn, MBBS, BSc, FRCP

As the evidence surrounding integrative oncology increases, there is a growing need for knowledge translation strategies to be developed, evaluated and implemented to support the transfer of research findings to both cancer patients and oncology health professionals. For this session, leaders in integrative medicine and translational science will present on novel knowledge translation tools. The challenge and facilitators of synthesizing and translating integrative oncology evidence into practice will also be discussed.

a.  Introduction to Knowledge Translation and Session
     Eva Grunfeld, MSc, MD, DPhil, FCFP
     DFCM Giblon Professor and Vice Chair, Research, Department of Family &
       Community Medicine, University of Toronto 
     Director, Knowledge Translation Research Network Health Services
        Program, Cancer Care Ontario/Ontario Institute for Cancer Research

b.  Natural Health Product-Drug Interactions: The Good, The Bad, and The Ugly
     Sunita Vohra, MD
     Professor, Department of Pediatrics, Faculty of Medicine & Dentistry, 
        University of Alberta 

     Patients are drawn to natural health products (NHPs), often because they 
     assume "natural" means "safe". Clinicians worry about NHP-drug interactions,
     but despite this, don't yet routinely inquire about patient NHP use. This talk will
     review strategies to promote patientcentered evidence-based practice while
     developing a population-based database about which NHP-drug
     combinations have been taken without adverse events, vs. those associated
     with potential harm.

c.  Shared Decision Making in Integrative Oncology: The MyChoices© Project
     Lynda Balneaves, PhD, RN
     Associate Director, Research and Associate Professor, School of Nursing,
       University of British Columbia
     Principal Investigator, The Complementary Medicine Education and
        Outcomes (CAMEO) Program
d.  Development and Use of Synthesis Knowledge in an Integrative Cancer Care
     Dugald Seely, ND, MSc
     Founder & Executive Director, Ottawa Integrative Cancer Centre
     Director of Research& Clinical Epidemiology, Canadian College of 
        Naturopathic Medicine

      Dr. Seely will review the process of working through a series of systematic
      reviews, including the use of meta-analysis on specific therapies relevant to
      integrative oncology. Discussion will cover some of the limitations and
      challenges of synthesizing, sharing, and using this type of evidence with a
      description of key components that feed into the process. Examples
      of actual tools used in an integrative oncology setting, including patient and
      professional monographs as well as the development of decision aids will be

e. “Lost in Translation”: Barriers to Knowledge Uptake in Integrative Oncology
     Dr. Michelle Kohn MB BS, BSc, FRCP
     Director, Living Well Programme, LOC - Leaders in Oncology Care, London,

f.  Moderated Discussion and Questions
    Eva Grunfeld, MSc, MD, DPhil, FCFP


Advances in Cancer Survivorship Research: Joint Session with the American Society of Preventive Oncology (ASPO)

MODERATORS: Wendy Demark-Wahnefried, PhD, RD
  Heather Greenlee, ND, PhD

Cancer survivors are frequent users of integrative therapies and there is significant overlap between "cancer survivorship research" and "integrative oncology research." For this session, the Society of Integrative Oncology has partnered with leaders from the American Society of Preventive Oncology to present on Advances in Cancer Survivorship Research. The session will include cutting edge presentations on behavior change research (Wendy Demark-Wahnefried, PhD, RD, University of Alabama at Birmingham), mind-body interventions (Anita Kinney, University of New Mexico), diet and physical activity interventions (Karen Basen-Enquist, MD Anderson Cancer Center), and survivorship research resources (Electra Paskett, Ohio State University Cancer Center). The presenters are all successful, federally funded researchers who are leaders in their respective fields. A goal of this joint SIO and ASPO session is to foster collaborative bridges between research organizations.

  1. Introduction to ASPO and Overlap Between "Cancer Survivorship" and "Integrative Oncology"
    Wendy Demark-Wahnefried, PhD, RD
    ASPO President
    Professor and Webb Endowed Chair of Nutrition Sciences, University of
       Alabama at Birmingham (UAB)

    Associate Director for Cancer Prevention and Control, UAB Comprehensive
       Cancer Center

  2. Behavior Change Research: Challenges and Solutions to Recruitment and Retention
    Wendy Demark-Wahnefried, PhD, RD

  3. Mind-body Research: Meaningful Interventions and Endpoints
    Anita Kinney, PhD
    Past Chair, ASPO Survivorship Special Interest Group
    Carolyn R. Surface Endowed Chair in Cancer Population Sciences; Professor,
       Internal Medicine, University of 
    New Mexico 
    Associate Director for Cancer Control and Population Sciences, University of
       New Mexico Cancer Center

  4. Exercise and Dietary Change Research: Novel Interventions and Endpoints
    Karen Basen-Engquist, PhD, MPH
    Chair, ASPO Survivorship Special Interest Group
    Professor of Behavioral Science, the Division of Cancer Prevention
       and Population Sciences, The University of Texas M. D. Anderson Cancer
    Director of Center for Energy Balance, Cancer Prevention and Survivorship

  5. Survivorship research resources: Women's Health Initiative (WHI) Cancer Survivor Cohort
    Electra Paskett, PhD
    Past President, ASPO
    Marion N. Rowley Professor of Cancer Research and Director, Division of
       Cancer Prevention and Control, Department of Internal Medicine, College of
       Medicine, Ohio State University

    Professor, Division of Epidemiology, College of Public Health, Ohio State

    Associate Director for Population Sciences, Comprehensive Cancer Center,
       Ohio State University

  6. Wrap-Up
    Heather Greenlee, ND, PhD

    SIO President Elect
    Assistant Professor of Epidemiology, Mailman School of Public Health,
       Columbia University

Mind-Body Interventions: From Immune Function to the Internet


Linda Carlson, PhD
Joanne Stephen, PhD
Susan Lutgendorf, PhD

Advances in basic science have made it possible for PNI researchers to better investigate a wide range of biobehavioral pathways that are specific to cancer progression and may be meaningful in the context of mind-body interventions designed to reduce stress and improve social support for cancer patients and survivors. In this symposium, Dr. Lutgendorf will first overview recent advances in our ability to study and detect stress influences in cancer markers and disease progression. Dr. Carlson will overview an example of clinical research on mindfulness-based and supportive interventions that affect a range of potentially important biomarkers in breast cancer survivors. Dr. Stephen will discuss the potential of disseminating mind-body interventions through the internet, with reference to research on an innovative pan-Canadian psychosocial intervention 'CancerChatCanada'.

a.  Stress Pathways and Tumor Progression: Recent Advances
     Susan Lutgendorf, PhD 
     Departments of Psychology, Obstetrics and Gynecology, and Urology,
        University of Iowa
     Member of the Holden Comprehensive Cancer Center, University of Iowa

b. Effects of Mindfulness‐Based Cancer Recovery and Supportive Expressive
    Therapy on Salivary Cortisol and Telomere Length in Breast Cancer Survivors
    Linda Carlson, PhD, CPsych
    Enbridge Research Chair in Psychosocial Oncology 
    Alberta Heritage Foundation for Medical Research Health Scholar
    Fellow in the Society of Behavioural Medicine
    Professor, Department of Oncology; Adjunct Associate Professor, Department of
       Psychology; University of Calgary
    Clinical Psychologist, Tom Baker Cancer Centre

c. Increasing the Reach of Mind‐Body Interventions: A Case Study in Therapist‐Led,
    Internet Support Groups
    Joanne Stephen, PhD
    Clinician Scientist, The BC Cancer Agency Psychosocial Oncology Program 
    Chair, National Alliance of Psychosocial Care Online 
    Chair, BC Cancer Agency, Fraser Valley Centre Patient and Family Counselling



Advances in Nutrition Therapy – The Microbiome

   MODERATORS: Paul Rogers, MD
  Elena J Ladas, PhD, RD

This session will present cutting edge research on the potential role of probiotics for chemoprevention and treatment of cancer. Presentation of a clinical trial describing the use of probiotics as a component of supportive care among children and adolescents will also be covered.

a.  The Microbiome and Cancer: Should We Ever Prescribe Bacteria?
     Gregory A. Plotnikoff, MD, MTS, FACP
Integrative Medicine Physician, Penny George Institute for Health and Healing 
     Senior Consultant, Center for Health Care Innovation, Allina Health Care 
     Co‐Editor, Global Advances in Health and Medicine

b.  The Microbiota at the Mucosal Luminal Interface: Lessons from Children with
      Inflammatory Bowel Disease
     David Mack, MD, FRCPC
Assistant Professor of Medicine, Department of Medicine / Medicine –
        Oncology, Duke University

c.  Probiotics and Tumor Suppression: Potentials and Limitations
     Satya Prakash, PhD
Professor, Biomedical Engineering, McGill University
     Member, Artificial Cells and Organs Research Centre 
     Associate Member, Physiology

d.  A Feasibility Trial of Lactobacillus Plantarum in Children Undergoing Stem
     Elena Ladas, PhD, RD
     Director, Integrative Therapies Program, Columbia University 
     Chair, Nutrition Committee of Children's Oncology Group, Adjunct Professor,
        Touro College


The Role of Cannabis in Integrative Oncology

   MODERATOR: Lynda Balneaves, PhD, RN

There has been a resurgence in interest and research focused on the role of cannabis in cancer care. This session will provide a historical, basic science and clinical overview of cannabis and its therapeutic potential in oncology. In addition, the experience of accessing and utilizing cannabis for therapeutic purposes will be discussed from the patient perspective.

a.  Introduction to Cannabis in Integrative Oncology
     Lynda Balneaves, PhD, RN
     Associate Director, Research and Associate Professor, School of Nursing,
        University of British Columbia 
     Principal Investigator, The Complementary Medicine Education and Outcomes
        (CAMEO) Program

b. Cannabis in Cancer Care
    Donald Abrams, MD
    Professor, UCSF School of Medicine 
    Chief, Hematology‐Oncology, San Francisco General Hospital
    Integrative Oncology, Osher Center for Integrative Medicine

c.  Cannabis from the Patient Perspective
     David Hutchison, Patient Advocate

d.  Moderated Discussion and Questions
     Lynda Balneaves, PhD, RN


Integrative Oncology Clinical Guidelines: Current and Future Guidelines from SIO

   MODERATOR: Gary Deng, MD, PhD 

The field of integrative oncology is rapidly growing and there is a need for clear, evidence-based clinical guidelines on the practice of integrative oncology. To date, SIO has published four separate evidence-based clinical guidelines. During this session, Gary Deng, MD, PhD (SIO Past President) and Heather Greenlee, ND, PhD (SIO President Elect), will present the recently published guidelines on the use of integrative oncology for lung cancer (CHEST, 2013), including the process for developing the guidelines and the clinical recommendations. Dr. Greenlee and Suzanna Zick, ND, MPH (SIO Executive Committee) will present the plans and process for developing future updated SIO clinical guidelines across multiple cancer types.

Gary Deng, MD, PhD
Associate Member/Attending Physician, Integrative Medicine Service, Memorial
   Sloan‐Kettering Cancer Center

Heather Greenlee, ND, PhD
SIO President Elect; Assistant Professor of Epidemiology, Mailman School of
   Public Health, Columbia University

Suzanna Zick, ND, MPH
Research Associate Professor, Department of Family Medicine, University of